Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice
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چکیده
منابع مشابه
Dihydromyricetin Protects against Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Mice
Diabetic cardiomyopathy (DCM) is an important cause of heart failure in diabetic patients. The present study sought to explore the potential effects of dihydromyricetin (DHM) on DCM and its possible mechanism. A diabetic model was induced by intraperitoneal injection of streptozotocin (STZ) in C57BL/6J mice. Two weeks after the STZ injection, mice were randomly allocated into the following 4 gr...
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The insulin-PI3K-mTOR pathway exhibits a variety of cardiovascular activities including protection against I/R injury. Lin28a enhanced glucose uptake and insulin-sensitivity via insulin-PI3K-mTOR signalling pathway. However, the role of lin28a on experimental cardiac I/R injury in diabetic mice are not well understood. Diabetic mice underwent 30 min. of ischaemia followed by 3 hrs of reperfusio...
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Objective(s): Protosappanin A (PrA) is an effective and major ingredient of Caesalpinia sappan L. The current study was aimed to explore the effect of PrA on atherosclerosis (AS). Materials and Methods: Firstly, the experimental model of AS was established in rabbits by two-month feeding of high fat diet. Then, the rabbits were randomly divided into five groups and treated with continuous high ...
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In both type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of β-cell, leading to the impaired insulin secretion. Here, we show that dietary supplementation of baicalein, a flavone isolated from the roots of Chinese herb Scutellaria baicalensis, improved glucose tolerance and enhanced gluco...
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Flavonoids are a complex group of plant-made phenolic Background: compounds that are considered of high nutraceutical value. Their beneficial impacts on human health relate predominantly to their capacity to serve as antioxidants, thus protecting cells against the damaging impact of reactive oxygen species. Recent studies have also pointed at an essential role for flavonoids as antioxidants in ...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2020
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.15026